Anti-USP7 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-USP7 Polyclonal Antibody
中文名称： 疱疹病毒相关泛素特异性蛋白酶7抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC
稀释比例： IHC 1:25-100.

抗体信息

靶标： USP7
别名： Deubiquitinating enzyme 7, herpes virus associated, Herpes virus associated ubiquitin specific protease, Herpesvirus-associated ubiquitin-specific protease, TEF 1, tef-1, TEF1, Ubiquitin carboxyl terminal hydrolase 7, Ubiquitin carboxyl-terminal hydrolase 7, Ubiquitin specific peptidase 7 (herpes virus associated), Ubiquitin specific peptidase 7, Ubiquitin specific peptidase 7 herpes virus associated, Ubiquitin specific processing protease 7, Ubiquitin Specific Protease 7, Ubiquitin specific protease 7 herpes virus associated, Ubiquitin thioesterase 7, ubiquitin thiolesterase 7, Ubiquitin-specific-processing protease 7, UBP 7, UBP-7, UBP7, UBP7_HUMAN, USP 7, usp-7, USP7, VMW110-ASSOCIATED PROTEIN, 135-KD
背景说明： Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards 'Lys-48'-linked Ubiquitin chains.
Swiss Prot： Q93009
Gene ID： 7874
亚细胞定位： Nucleus
免疫原： A synthetic peptide of human USP7
理论分子量： 128/126kDa

其它标识

纯化方法： Affinity purification
储存液： pH7.4 PBS，0.05% NaN3，40% Glycerol.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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