Anti-TMED2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-TMED2 Polyclonal Antibody
中文名称： 跨膜PEN24结构域蛋白2抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC ; WB
稀释比例： WB 1:500-2000.IHC 1:25-100.

抗体信息

靶标： TMED2
别名： coated vesicle membrane protein, Membrane protein p24A, p24, p24 family protein beta-1, P24A, p24beta1, RNP24, Sid 394, Sid394, TMED2, TMED2_HUMAN, transmembrane emp24 domain trafficking protein 2, Transmembrane emp24 domain-containing protein 2
背景说明： Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.
Swiss Prot： Q15363
Gene ID： 10959
亚细胞定位： Cytoplasm
免疫原： Recombinant protein of human TMED2
理论分子量： 23kDa

其它标识

纯化方法： Affinity purification
储存液： pH7.4 PBS，0.05% NaN3，40% Glycerol.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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