Anti-RAN Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-RAN Polyclonal Antibody
中文名称： 雄激素受体相关蛋白24抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC ; WB
稀释比例： WB 1:2000-5000. IHC 1:10-100.

抗体信息

靶标： RAN
别名： Androgen receptor associated protein 24, Androgen receptor-associated protein 24, ARA 24, ARA24, Gsp1, GTP binding nuclear protein RAN, GTP-binding nuclear protein Ran, GTPase Ran, LPS, ran, RAN member RAS oncogene family, RAN_HUMAN, Ras like protein TC4, Ras related nuclear protein, Ras-like protein TC4, Ras-related nuclear protein, RASL2 8, TC 4, TC4
背景说明： RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
Swiss Prot： P62826
Gene ID： 5901
亚细胞定位： Cytoplasm Melanosome Nucleus Nucleus envelope
免疫原： A synthetic peptide of human RAN
理论分子量： 24kDa

其它标识

纯化方法： Affinity purification
储存液： pH7.4 PBS，0.05% NaN3，40% Glycerol.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

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