Anti-RICTOR Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-RICTOR Polyclonal Antibody
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Human
应用： ELISA ; IF ; IHC ; WB
稀释比例： WB 1:1000-8000. IHC 1:50-500. IF 1:50-500.

抗体信息

靶标： RICTOR
别名： AVO3 homolog;hAVO3;KIAA1999;mAVO3;RICTOR
背景说明： Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
Swiss Prot： Q6R327
Gene ID： 253260
亚细胞定位： Cytoplasm
免疫原： Recombinant protein of human RICTOR
Public Immunogen Range： 1-51aa
理论分子量： 192kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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