Anti-NTRK2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-NTRK2 Polyclonal Antibody
中文名称： 神经营养酪氨酸激酶受体2型抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Human预测
交叉反应：： Mouse
应用： ELISA ; FCM ; IF ; IHC ; WB
稀释比例： WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. FCM 1μg/Test. IF 1:100-500.

抗体信息

靶标： NTRK2
别名： TrkB;NTRK2;Tyrosine Receptor Kinase B;Tyrosine kinase,Pyk2;BDNF tropomyosine receptor kinase B;BDNF/NT 3 growth factors receptor
背景说明： Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
Swiss Prot： Q16620
Gene ID： 4915
亚细胞定位： Cell membrane Endosome membrane Single-pass type I membrane protein
免疫原： A synthetic peptide of human NTRK2
Public Immunogen Range： 401-500/822aa
理论分子量： 35/53/59/60/81/91/93kDa

其它标识

纯化方法： Affinity purification
储存液： 0.01M TBS(pH7.4) with 1% BSA，0.03% Proclin300 and 50% Glycerol.
储存条件： Store at -20℃. Avoid freeze / thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

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2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。