Anti-Phospho-IKK alpha/beta (Ser176 + Ser180) Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-Phospho-IKK alpha/beta (Ser176 + Ser180) Polyclonal Antibody
中文名称： 磷酸化KB抑制蛋白激酶α/β抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Human预测
交叉反应：： Rat;Chicken;Dog;Pig;Cow;Horse
应用： ELISA ; IF ; IHC
稀释比例： ELISA 1:5000-10000. IHC 1:100-500. IF 1:100-500.

抗体信息

靶标： Phospho-IKK alpha/beta (Ser176 + Ser180)
别名： IKK alpha (phospho S176 + S180);p-IKK alpha (phospho S176 + S180);I Kappa B Kinase Alpha;IKKalpha;IKK alpha;IkappaB kinase;IkB kinase alpha subunit;IKBKA;IKK 1;IKK A;IKK a kinase;IKK1;IKKA;Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells;Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit;NFKBIKA;Nuclear Factor Kappa B Inhibitor Kinase Alpha
背景说明： Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3.
Swiss Prot： O15111
Gene ID： 1147
亚细胞定位： Cytoplasm Nucleus
免疫原： A synthetic peptide of human IKK alpha/beta around the phosphorylation site of Ser176/Ser180
理论分子量： 85/87kDa

其它标识

纯化方法： Affinity purification
储存液： 0.01M TBS(pH7.4) with 1% BSA，0.03% Proclin300 and 50% Glycerol.
储存条件： Store at -20℃. Avoid freeze / thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。