Anti-Phospho-KIT(Tyr721) Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-Phospho-KIT(Tyr721) Polyclonal Antibody
中文名称： 原癌基因蛋白c-kit抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Human预测
交叉反应：： Rat;Dog;Pig;Cow;Horse
应用： ELISA ; FCM ; IF ; IHC
稀释比例： ELISA 1:5000-10000. IHC 1:100-500. FCM 1ug/test. IF 1:100-500.

抗体信息

靶标： Phospho-KIT(Tyr721)
别名： c-Kit (phospho Y721);c-Kit (phospho Tyr721);p-c-Kit (Tyr 721);C Kit;c-Kit;CD 117;CD117;CD117 antigen;KIT;KIT_HUMAN;Mast/stem cell growth factor receptor;Mast/stem cell growth factor receptor Kit;p145 c-kit;PBT;Piebald trait protein;Proto oncogene c Kit;Proto oncogene tyrosine protein kinase Kit;Proto-oncogene c-Kit;SCF Receptor;SCFR;soluble KIT variant 1
背景说明： Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.
Swiss Prot： P10721
Gene ID： 3815
亚细胞定位： Cytoplasm Cell membrane
免疫原： A synthetic peptide of human KIT around the phosphorylation site of Tyr721
理论分子量： 47/109kDa

其它标识

纯化方法： Affinity purification
储存液： 0.01M TBS(pH7.4) with 1% BSA，0.03% Proclin300 and 50% Glycerol.
储存条件： Store at -20℃. Avoid freeze / thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
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注意事项 Considerations

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