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Anti-Lin28B Polyclonal Antibody,BR

Anti-Lin28B Polyclonal Antibody

(订货以英文名为准)
产品编号:AC58229 品牌:Acmec
中文名称:
Anti-Lin28B Polyclonal Antibody
英文名称:
Anti-Lin28B Polyclonal Antibody
保存条件:
-20℃

产品属性 Product Attributes

基本信息

英文名称: Anti-Lin28B Polyclonal Antibody
中文名称: RNA结合蛋白LIN28B抗体
规格: 50ul ; 100ul
宿主: Rabbit
克隆类型: Polyclonal Antibody
亚型: IgG
交叉反应:: Rat ; Human预测
交叉反应:: Mouse;Chicken;Pig;Cow;Horse;Rabbit;Sheep
应用: ELISA ; IF ; IHC ; WB
稀释比例: WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. IF 1:50-200.

抗体信息

靶标: Lin28B
别名: Lin28B;CSDD 2;CSDD2;FLJ16517;Lin 28 homolog B (C. elegans);Lin 28.2;Lin-28B;LIN28B;LN28B_HUMAN;Protein lin-28 homolog B
背景说明: Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.
Swiss Prot: Q6ZN17
Gene ID: 389421
亚细胞定位: Nucleus Cytoplasm
免疫原: A synthetic peptide of human Lin28B
Public Immunogen Range: 65-160/250aa
理论分子量: 27kDa

其它标识

纯化方法: Affinity purification
储存液: 0.01M TBS(pH7.4) with 1% BSA,0.03% Proclin300 and 50% Glycerol.
储存条件: Store at -20℃. Avoid freeze / thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响,相关处理只限于产品本身,不涉及其他赔偿。
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