Anti-DAB2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-DAB2 Polyclonal Antibody
中文名称： 信号转导功能磷蛋白DAB2抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： ELISA ; WB ; IHC
稀释比例： WB 1:500-2000. IHC 1:50-200. ELISA 1:2000-5000.

抗体信息

靶标： DAB2
别名： DAB 2, DAB2, DAB2_HUMAN; Differentially expressed protein 2, Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein), disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein), Disabled homolog 2, Disabled homolog 2 mitogen responsive phosphoprotein (Drosophila), Disabled homolog 2 mitogen responsive phosphoprotein, disabled homolog 2 mitogen-responsive phosphoprotein (Drosophila), DOC 2, DOC2, FLJ26626, Mitogen responsive phosphoprotein
背景说明： This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Swiss Prot： P98082
Gene ID： 1601
亚细胞定位： Cytoplasm Nucleus
免疫原： Recombinant protein of human DAB2
理论分子量： 82 kDa

其它标识

纯化方法： Affinity Purification
储存液： pH7.4 PBS，0.05% NaN3，40% Glycerol.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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