Anti-SMAD7 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-SMAD7 Polyclonal Antibody
中文名称： Smad7抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Rat ; Human
应用： IHC
稀释比例： IHC 1:50-200.

抗体信息

靶标： SMAD7
别名： CRCS3;MADH7;MADH8;Hsmad7;MAD homolog 8
背景说明： Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Swiss Prot： O15105
Gene ID： 4092
亚细胞定位： Cytoplasm Nucleus
免疫原： A synthetic peptide of human SMAD7
Public Immunogen Range： 350-400/426aa
理论分子量： 46kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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