Anti-FGFR4 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-FGFR4 Polyclonal Antibody
中文名称： 成纤维细胞生长因子受体4抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Human
应用： WB ; IHC
稀释比例： WB 1:5000-8000. IHC 1:100-300.

抗体信息

靶标： FGFR4
别名： FGFR4;CD334;JTK2;TKF;fibroblast growth factor receptor 4
背景说明： The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Swiss Prot： P22455
Gene ID： 2264
亚细胞定位： Cytoplasm Cell membrane
免疫原： A synthetic peptide of human FGFR4
Public Immunogen Range： 125-175/802aa
理论分子量： 64/83/87kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
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注意事项 Considerations

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