Anti-CDKN2A Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-CDKN2A Polyclonal Antibody
中文名称： 抑癌基因p16抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Mouse
应用： IHC
稀释比例： IHC 1:25-100.

抗体信息

靶标： CDKN2A
别名： CDKN2A;ARF;CDK4I;CDKN2;CMM2;INK4;INK4A;MLM;MTS-1;MTS1;P14;P14ARF;P16;P16-INK4A
背景说明： This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.
Swiss Prot： P42771
Gene ID： 1029
亚细胞定位： Nucleus Cytoplasm
免疫原： A synthetic peptide of human CDKN2A
Public Immunogen Range： 15-65/147aa
理论分子量： 17/11/14kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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