Anti-GDF1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-GDF1 Polyclonal Antibody
中文名称： 生长分化因子1抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human
应用： IHC
稀释比例： IHC 1:50-200.

抗体信息

靶标： GDF1
别名： DORV;DTGA3;Embryonic growth/differentiation factor 1;GDF 1;GDF-1;GDF1;GDF1_HUMAN;Growth differentiation factor 1;
背景说明： Growth and Differentiation Factor 1 (GDF 1) is a secreted protein in the TGF beta superfamily (1). It is the functional equivalent of frog, zebrafish, and chick Vg1 (2, 3). Human GDF 1 is synthesized as a preproprotein that produces an approximately 44 kDa proprotein after cleavage of a 29 amino acid (aa) signal peptide. Further proteolysis at a dibasic cleavage site produces a 224 aa propeptide and a secreted 119 aa, 12 15 kDa mature peptide (4). Mature human GDF 1 shares 81% aa sequence identity with mouse and rat GDF 1. GDF 1 is expressed in the developing and adult nervous system, particularly in neurons of the cerebral cortex and hippocampus (4, 5). It is required during embryogenesis for development of left/right axis asymmetry, anterior/posterior axis asymmetry, and the notochord (2, 3, 6, 7). It cooperates with Nodal and GDF 3 in these activities and potentiates Nodal bioactivity through formation of a 27 kDa noncovalent GDF 1 Nodal heterodimer (3, 7, 8). The presence of Nodal is required for GDF 1 induced effects (8). GDF 1 signals through heteromeric receptor complexes containing Activin RIIA or Activin RIIB, ALK4 or ALK7, and an EGF CFC protein such as Cryptic or Cripto (7 9). Loss of function mutations in GDF 1 are associated with a variety of human cardiac development defects (10).
Swiss Prot： P27539
Gene ID： 2657
亚细胞定位： Secreted
免疫原： A synthetic peptide of human GDF1
Public Immunogen Range： 90-140/372aa
理论分子量： 39/45kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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