Anti-CELF1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-CELF1 Polyclonal Antibody
中文名称： 胞苷尿苷鸟苷结合蛋白1抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Human
应用： WB
稀释比例： WB 1:1000-3000.

抗体信息

靶标： CELF1
别名： 50 kDa Nuclear polyadenylated RNA binding protein;50 kDa nuclear polyadenylated RNA-binding protein;Bruno like 2;bruno like protein 2;Bruno-like protein 2;BRUNOL 2;BRUNOL2;CELF 1;CELF-1;celf1;CELF1 CUGBP, Elav like family member 1;CELF1_HUMAN;CUG BP and ETR 3 like factor 1;CUG BP;CUG BP1;CUG RNA binding protein;CUG triplet repeat RNA binding protein 1;CUG triplet repeat RNA-binding protein 1;CUG-BP;CUG-BP- and ETR-3-like factor 1;CUG-BP1;CUGBP 1;CUGBP and ETR3 like factor 1;CUGBP;CUGBP Elav like family member 1;CUGBP Elav-like family member 1;CUGBP1;Cytidine uridine guanosine binding protein 1;Deadenylation factor CUG BP;Deadenylation factor CUG-BP;Deadenylation factor CUGBP;EDEN BP;EDEN BP homolog;EDEN-BP;EDEN-BP homolog;embryo deadenylation element binding protein;embryo deadenylation element binding protein homolog;Embryo deadenylation element-binding protein homolog;hNab 50;hNab50;NAB 50;NAB50;NAPOR;Nuclear polyadenylated RNA binding protein 50 kD;Nuclear polyadenylated RNA binding protein;RNA binding protein BRUNOL 2;RNA binding protein BRUNOL2;RNA-binding protein BRUNOL-2;
背景说明： RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA.
Swiss Prot： Q92879
Gene ID： 10658
亚细胞定位： Nucleus Cytoplasm
免疫原： A synthetic peptide of human CELF-1
Public Immunogen Range： 1-51/486aa
理论分子量： 50/52/55kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。