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- Anti-UBE2O Polyclonal Antibody,BR
Anti-UBE2O Polyclonal Antibody,BR
Anti-UBE2O Polyclonal Antibody
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产品属性 Product Attributes
基本信息
英文名称: Anti-UBE2O Polyclonal Antibody中文名称: 泛素联接酶E2O抗体
规格: 50ul ; 100ul
宿主: Rabbit
克隆类型: Polyclonal Antibody
亚型: IgG
交叉反应:: Human ; Rat ; Mouse
应用: IHC
稀释比例: IHC 1:100-300.
抗体信息
靶标: UBE2O别名: KIAA1734;E2/E3 hybrid ubiquitin-protein ligase UBE2O;Ubiquitin carrier protein O;Ubiquitin-conjugating enzyme E2 O;Ubiquitin-conjugating enzyme E2 of 230 kDa;Ubiquitin-conjugating enzyme E2-230K;Ubiquitin-protein ligase O;(E3-independent) E2 ubiquitin-conjugating enzyme ;
背景说明: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).
Swiss Prot: Q9C0C9
Gene ID: 63893
亚细胞定位: Cytoplasm Nucleus
免疫原: Recombinant protein of human UBE2O
Public Immunogen Range: 1-350aa
理论分子量: 141kDa
其它标识
纯化方法: Affinity purification储存液: PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3.
储存条件: Store at -20℃. Avoid freeze/thaw cycles.
产品介绍 Product Introduction
使用前请离心。如有问题请及时联系我们。Quick spin before use. If you have any questions, please contact us.
注意事项 Considerations
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响,相关处理只限于产品本身,不涉及其他赔偿。