Anti-IDH1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-IDH1 Polyclonal Antibody
中文名称： 可溶性异柠檬酸脱氢酶1（NADP+）抗体
规格： 50ul ; 100ul ; 20ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应： Human ; Rat ; Mouse预测
交叉反应： Cow(100%);Sheep(100%);Chimpanzee(100%);Vole(100%)
应用： IHC-P
稀释比例： IHC-P 1:50-200.

抗体信息

靶标： IDH1
别名： IDH1;HEL-216;HEL-S-26;IDCD;IDH;IDP;IDPC;PICD
背景说明： Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Swiss Prot： O75874
Gene ID： 3417
亚细胞定位： Cytoplasm Nucleus
研究领域： 肿瘤&癌症 ; 细胞生物学 ; 信号传导
免疫原： A synthetic peptide of human IDH1 种属同源性预测Public Immunogen Range 350-400/414aa
理论分子量： 47kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.
运输条件： 冷冻运输 种属同源性预测

产品介绍 Product Introduction

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