Anti-HSPA5 Monoclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-HSPA5 Monoclonal Antibody
中文名称： 葡萄糖调节蛋白78/热休克蛋白70蛋白5抗体
规格： 50ul ; 100ul
宿主： Mouse
克隆类型： Monoclonal Antibody
亚型： IgG1克隆号 8G3
交叉反应：： Human ; Pig ; Rat
应用： WB ; IHC
稀释比例： WB 1:1000-3000. IHC 1:100-300.

抗体信息

靶标： HSPA5
别名： BIP, HSPA5, GRP-78, glucose regulated protein 78, 78 kDa glucose regulated protein, BIP, Endoplasmic reticulum lumenal Ca2+ binding protein grp78, FLJ26106, Glucose Regulated Protein 78kDa, GRP 78, Heat Shock 70kDa Protein 5, HSPA 5, HSPA-5, Immunoglobulin Heavy Chain Binding Protein, MIF2, GRP78_HUMAN
背景说明： Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) . In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating.
Swiss Prot： P11021
Gene ID： 3309
亚细胞定位： Cytoplasm
免疫原： Synthetic Peptide
理论分子量： 72kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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