Recombinant Mouse Inducible T-cell Costimulator/ICOS/CD278,BR

产品属性 Product Attributes

基本信息

别名： Inducible T-cell costimulator;Activation-inducible lymphocyte immunomediatory molecule;CD28 and CTLA-4-like protein;CCLP;CD28-related protein 1;CRP-1;CD278;Icos;Ailim
中文名称: Recombinant Mouse Inducible T-cell Costimulator/ICOS/CD278
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Inducible Costimulator(ICOS) is a member of the growing CD28 family of immune costimulatory receptors.Other family members are CD28，CTLA4 and PD1.ICOS shares approximately 39% amino acid similarity with CD 28 and CTLA4.Mouse and human ICOS share approximately 72% amino acid identity.ICOS is expressed on most CD45RO+ cells.ICOS expression is up-regulated within approximately 24-48 hours of activation on Th primed cells.B7-H2，a member of the B7 family of costimulatory ligands，has been identified as the ICOS ligand.The B7-H2/ ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.In addition，ICOS is more potent in the induction of IL-10 production，acytokine important for suppressive function of T regulatory cells.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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