Recombinant Human KRAS(G12S),BR

产品属性 Product Attributes

基本信息

别名： Ki-Ras;c-K-ras;KRAS2;RASK2;CFC2
英文名称： Recombinant Human KRAS(G12S)
中文名称： Recombinant Human KRAS(G12S)
规格： 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度： ≥95% as determined by reducing SDS-PAGE.
储存条件： Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months.
运输条件： 冷藏运输

产品信息

背景说明： K-Ras belongs to the small GTPase superfamily，Ras family.As other members of the Ras family，K-Ras is a GTPase and is an early player in many signal transduction pathways.It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus.K-Ras functions as a molecular on/off switch.Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.Plays an important role in the regulation of cell proliferation.Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.Besides essential function in normal tissue signaling，the mutation of a K-Ras gene is an essential step in the development of many cancers.Several germline K-Ras mutations have been found to be associated with Noonan syndrome[4] and cardio-facio-cutaneous syndrome.Somatic K-Ras mutations are found at high rates in Leukemias，colon cancer，pancreatic cancer and lung cancer.
来源： E.coli

其它标识

溶剂： Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素： Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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