Recombinant Cynomolgus B7-1/CD80/T-lymphocyte Activation Antigen CD80,BR

产品属性 Product Attributes

基本信息

别名： T-lymphocyte activation antigen CD80;Activation B7-1 antigen;B7;CD80
中文名称: Recombinant Cynomolgus B7-1/CD80/T-lymphocyte Activation Antigen CD80
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Cynomologous Cluster of Differentiation 80，also called B7-1，is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells，macrophages and dendritic cells.CD80 plays key，yet distinct roles in the activation of T cells.B7-1/CD80 and B7-2/CD86，together with their receptors CD28 and CTLA4，constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses.CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells，macrophages and dendritic cells.Although both CTLA-4 and CD28 can bind to the same ligands，CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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