Recombinant Mouse Kirrel1/NEPH1/nephrin-like protein 1,BR

产品属性 Product Attributes

基本信息

别名： Kin of IRRE-like protein 1;Kin of irregular chiasm-like protein 1;Nephrin-like protein 1;Kirrel1;Neph1
中文名称: Recombinant Mouse Kirrel1/NEPH1/nephrin-like protein 1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Kin of irregular chiasm-like protein 1(Kirrel1)，also known as Nephrin-like protein 1(Neph1)，belongs to the immunoglobulin superfamily.Kirrel1 plays a significant role in the normal development and function of the glomerular permeability.It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.The knockout of this gene could result in perinatal lethality accompanied by proteinuria，and effacement of glomerular podocytes.Kirrel1 is abundantly expressed in kidney and specifically expressed in podocytes of kidney glomeruli.Its’ subunit interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus) and interacts with NPHS1/nephrin (via the Ig-like domains).This interaction is dependent on KIRREL glycosylation.Kirrel1 also interacts when tyrosine-phosphorylated with GRB2.
来源： Human Cells

其它标识

溶剂: Dissolve the lyophilized protein in distilled water.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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