Recombinant Human SLAMF7/CD319/CRACC,BR

产品属性 Product Attributes

基本信息

别名： SLAM Family Member 7;CD2 Subset 1;CD2-Like Receptor-Activating Cytotoxic Cells;CRACC;Membrane Protein FOAP-12;Novel Ly9;Protein 19A;CD319;SLAMF7;CS1
中文名称: Recombinant Human SLAMF7/CD319/CRACC
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain.SLAMF7 is expressed in NK cells，activated B-cells，NK-cell line but not in promyelocytic，B-cell lines，or T-cell lines.Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM)，which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A)，it activates NK cells in the absence of a functional SAP.SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP.However，in the absence of EAT-2，CRACC potently inhibited natural killer cell function.It was also inhibitory in T cells，which are typically devoid of EAT-2.Thus，SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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