Recombinant Human MICA/MHC-I related sequence A,BR

产品属性 Product Attributes

基本信息

别名： MHC Class I Polypeptide-Related Sequence A;MIC-A;MICA;PERB11.1
中文名称: Recombinant Human MICA/MHC-I related sequence A
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： MHC Class I Polypeptide-Related Sequence A (MICA) is a transmembrane glycoprotein that functions as a ligand for human NKG2D.Unlike classical MHC class I molecules，MICA does not form a heterodimer with beta-2-microglobulin.MICA shares 85% amino acid identity with a closely related protein，MICB.MICA acts as a stress-induced self-antigen that is recognized by NK cells，NKT cells，and most of the subtypes of T cells.As a Ligand for the KLRK1/NKG2D receptor，MICA binds to KLRK1 leads to cell lysis.MICA functions as an antigen for gamma delta T cells and is frequently expressed in epithelial tumors.MICA antigens are able to elicit the synthesis of alloantibodies in transplant recipients.Studies have shown that anti-MICA antibodies are associated with acute renal allograft rejection and failure.MICA recognition is involved in tumor surveillance，viral infections，and autoimmune diseases.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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