Recombinant Human TSLP,BR

产品属性 Product Attributes

基本信息

别名： Thymic stromal lymphopoietin;TSLP
中文名称: Recombinant Human TSLP
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7.The human TSLP protein comprises a 28 amino acids (aa) signal sequence and 131 aa mature region.Human TSLP has two isoforms lfTSLP and sfTSLP produced by alternative splicing.lfTSLP is expressed in a number of tissues including heart，liver and prostate，and sfTSLP (63aa) is predominantly expressed in keratinocytes of oral mucosa，skin and in salivary glands.In aa sequence level，Human TSLP displays about 43% identity with mouse TSLP.TSLP is a cytokine that functions mainly on myeloid cells; it induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells.TSLP has proliferative effects on the myeloid cell line and may initiate asthma or atopic dermatitis responses by directly activating mast cells.TSLP signals cells via the interleukin-7 receptor-α chain (IL-7Rα)，shared with IL-7，together with the TSLP receptor (TSLPR) subunit.Recent studies indicate that TSLP and its receptor are novel therapeutic targets for rheumatoid arthritis，for increased intraarticular TSLP concentrations in patients has caused chemotaxis and activation of arthritogenic T cells.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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