Recombinant Mouse Podoplanin,BR

产品属性 Product Attributes

基本信息

别名： Podoplanin;Aggrus;Glycoprotein 38;Gp38;PA2.26 antigen;T1-alpha;T1A
中文名称: Recombinant Mouse Podoplanin
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Podoplanin belongs to the podoplanin family，also known as Glycoprotein 38.Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence，a 119 aa extracellular domain (ECD)，a 21 aa transmembrane region，and a short，10 aa cytoplasmic tail.Detected at high levels in lung and brain，at lower levels in kidney，stomach，liver，spleen and esophagus，and not detected in skin and small intestine.Expressed in epithelial cells of choroid plexus，ependyma，glomerulus and alveolus，in mesothelial cells and in endothelia of lymphatic vessels.Also expressed in stromal cells of peripheral lymphoid tissue and thymic epithelial cells.Detected in carcinoma cell lines and cultured fibroblasts.Expressed at higher levels in colon carcinomas than in normal colon tissue.It can interacts with CLEC1B; the interaction is independent of CLEC1B glycosylation and activates CLEC1B.It may be involved in cell migration and/or actin cytoskeleton organization.When expressed in keratinocytes，induces changes in cell morphology with transfected cells showing an elongated shape，numerous membrane protrusions，major reorganization of the actin cytoskeleton，increased motility and decreased cell adhesion.Required for normal lung cell proliferation and alveolus formation at birth.Ligand for CLEC1B，a platelet receptor.Induces platelet aggregation.Does not have any effect on folic acid or amino acid transport.Does not function as a water channel or as a regulator of aquaporin-type water channels.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。