Recombinant Human Fc gamma RIIA/CD32a (R167),BR

产品属性 Product Attributes

基本信息

别名： Low Affinity Immunoglobulin Gamma Fc Region Receptor II-a;IgG Fc receptor II-a;CDw32;Fc-Gamma RII-a;Fc-Gamma-RIIa;FcRII-a;CD32;FCGR2A;CD32;FCG2;FCGR2A1;IGFR2
中文名称: Recombinant Human Fc gamma RIIA/CD32a (R167)
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Receptors for the Fc region of IgG (FcγR) are members of the Ig superfamily that function in the activation or inhibition of immune responses.Human FcγRs are divided into three classes designated FcγRI (CD64)，FcγRII (CD32)，and FcγRIII (CD16)，which generate multiple isoforms，are recognized.The activating- type receptor either has or associates non-covalently with an accessory subunit that has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain.FcγRI binds IgG with high affinity and functions during early immune responses，whereas FcγRII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses.Three genes for human FcγRII (A，B，and C) and one for mouse (FcγRIIB)，encoding type I transmembrane proteins with ITAM motifs (FcγRII A and C) or ITIM motifs (FcγRIIB) in their cytoplasmic domains，have been identified.Human CD32，also known as Low affinity immunoglobulin γ Fc region receptor II-a (IgG Fc receptor II-a)，FcγRII A or FCGR2A Protein，is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin.Associated with an ITAM-bearing adapter subunit，FcRγ，CD32a (FcγRII A) delivers an activating signal upon ligand binding，and results in the initiation of inflammatory responses including cytolysis，phagocytosis，degranulation，and cytokine production.The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fcγ RII B，and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

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