Recombinant Mouse LILRB4/CD85k/ILT3,BR

产品属性 Product Attributes

基本信息

别名： Leukocyte immunoglobulin-like receptor subfamily B member 4;Mast cell surface glycoprotein Gp49B;CD85k;Lilrb4;Gp49b
中文名称: Recombinant Mouse LILRB4/CD85k/ILT3
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCl, 100mM Glycine, pH 7.5.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Mouse Leukocyte Immunoglobulin-like Receptor Subfamily B Member 4 (LILRB4/CD85k/ILT3) is an approximately transmembrane glycoprotein that negatively regulates immune cell activation.Mouse LILRB4 consists of a 215 amino acid (aa) extracellular domain with two Ig-like domains，a 22 aa transmembrane segment，and a 75 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs (ITIM).Within the ECD，mouse LILRB4 shares 45% and 77% aa sequence identity with human and rat LILRB4，respectively.Alternative splicing of mouse LILRB4 generates a potentially soluble isoform that lacks the transmembrane segment.LILRB4 is expressed on dendritic cells (DC)，monocytes，macrophages，and vascular endothelial cells (EC).Ligation of LILRB4 triggers ITIM-mediated inhibition of cellactivating signaling，leading to enhanced immune tolerance and reduced allogeneic graft rejection.Soluble LILRB4 induces the differentiation of CD8+ T suppressor cells (Ts) that can inhibit the effector functions of CD4+ Th cells and CD8+ CTL.In turn，CD8+ Ts cells induce LILRB4 up-regulation and a tolerogenic phenotype in monocytes，DC，and EC.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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