Recombinant Human Thrombospondin-1/THBS1/TSP-1,BR

产品属性 Product Attributes

基本信息

别名： Thrombospondin-1;THBS1;TSP;TSP1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥85% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Thrombospondin-1 (TSP-1) is a 150-180kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer.TSP-1 regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM).TSP-1 contains an N-terminal Laminin G-like globular domain，an extended central region with one vWFC domain，3 TSP type 1domains，2 EGF-like domains，and 8 TSP type3 domains，and a globular TSP C-terminal domain.Distinct regions of TSP-1 have been associated with binding to particular ECM or cellular molecules.TSP-1 counteracts the angiogenic，hypotensive，and antithrombotic effects of nitric oxide (NO).It binds and neutralizes VEGF，blocks VEGF R2 signaling on vascular endothelial cells(EC)，and destabilizes adhesive contacts between EC.TSP-1 also plays an important role in wound repair and tissue fibrosis by binding latent TGF-beta and inducing release of the active cytokine from the latency associated peptide (LAP).
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

暂无数据

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。