Recombinant Cynomolgus TIM-3/HAVCR2,BR

产品属性 Product Attributes

基本信息

别名： T cell immunoglobulin and mucin domain3;HAVCR2;Tim-3;TIM3
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules.Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD)，a 21 aa transmembrane segment，and a 78 aa cytoplasmic tail.TIM3 is up-regulated on several populations of activated myeloid cells (macrophage，monocyte，dendritic cell，microglia，mast cell) and T cells (Th1，CD8+，NK，Treg).Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity.TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells.TIM3 interactions with Galectin-9 can trigger immune stimulatory effects，such as the coactivation of NK cell cytotoxicity.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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