Recombinant Mouse IL-4 R alpha/CD124/IL-4RA/IL-4R/Interleukin-4 Receptor Subunit Alpha/prot,BR

产品属性 Product Attributes

基本信息

别名： Interleukin-4 receptor subunit alpha;IL-4R-alpha;CD124;IL4-BP;Soluble IL-4R-alpha;IL-4RA
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Interleukin-4 receptor subunit alpha(IL-4RA)，alos known as Soluble IL-4 receptor subunit alpha，belongs to the type I cytokine receptor family and type 4 subfamily.It expressed in both Th1 and Th2 cells.It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway.The IL4 response is involved in promoting Th2 differentiation.The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic inflammation.In certain cell types，IL-4RA can signal through activation of insulin receptor substrates，IRS1/IRS2.The functional IL4 receptor is formed by initial binding of IL4 to IL4R.Subsequently it recruits to the complex of the common gamma chain.In immune cells，IL-4RA creates a type I receptor.In non-immune cells，it forms a type II receptor with of IL13RA1.IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases，PTPN6/SHIP1，PTPN11/SHIP2 and INPP5D/SHIP.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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