Recombinant Human HER2/CD340/ERBB2/Receptor Tyrosine-Protein Kinase ErbB-2,BR

产品属性 Product Attributes

基本信息

别名： Receptor tyrosine-protein kinase erbB-2;Metastatic lymph node gene 19 protein;Proto-oncogene Neu;Tyrosine kinase-type cell surface receptor HER2;ERBB2;MLN19;NGL;TKR1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein，and belongs to the epidermal growth factor (EGF) receptor family.HER2 plays a key role in development，cell proliferation and differentiation.HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas，including breast，prostate，ovarian，lung cancers and so on.HER2 is activated by dimerization and not activated by EGF，TGF-alpha and amphiregulin.Interaction with PTK6 increases its intrinsic kinase activity.It is heterodimer with EGFR，ERBB3 and ERBB4.HER2 associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription.It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC.And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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