Recombinant Mouse VISTA/B7-H5/Gi24/C10orf54/PD-1H/platelet receptor Gi24,BR

产品属性 Product Attributes

基本信息

别名： Platelet receptor Gi24;stress induced secreted protein 1;Dies1;VISTA;SISP1;B7-H5;PD-1H;GI24
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Mouse Platelet receptor Gi24(VISTA) is a transmembrane glycoprotein with homology to B7like immune costimulatory molecules.Mature mouse Gi24 contains a 159 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain，a 21 aa transmembrane segment，and a 97 aa cytoplasmic domain.VISTA promotes both MT1-MMP expression and the MT1-MMP mediated activation of MMP-2.It supports the differentiation of embryonic stem cells (ESC) and enhances BMP-4 induced signaling in ESC，but it is also down-regulated following BMP-4 exposure.It binds to BMP-4 directly and also associates with the type I BMP receptor Activin RIB/ALK-4.It is expressed on the surface of native CD4+ T cells and regulatory T cells.It is up-regulated in vivo on activated monocytes and dendritic cells.VISTA inhibits CD4+ and CD8+ T cell proliferation and their production of IL-2 and IFN-γ.Its expression on tumor cells attenuates the antitumor immune response and enables more rapid tumor progression.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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