Recombinant Mouse DNAX Accessory Molecule-1/DNAM-1/CD226,BR

产品属性 Product Attributes

基本信息

别名： CD226 antigen;platelet and T cell activation antigen 1;CD226 molecule;DNAM1 adhesion glycoprotein;DNAM-1;DNAX accessory molecule-1;DNAX accessory molecule 1;PTA1;T lineage-specific activation antigen 1 antigen;CD226;PTA1;TLiSA1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Mouse DNAX accessory molecule-1(DNAM-1) is a type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily.As an activating receptor，it interacts with the ligands CD155 and CD112，and activates natural killer (NK) cells via its immu-noreceptor tyrosine-based activatory motif (ITAM).Mature mouse DNAM-1 has extracellular domain (ECD) that contains two Ig-like C2-set domains，and possesses a cytoplasmic region that contains motifs for binding PDZ domains.DNAM-1 is expressed on several lymphoid and myeloid cell types and interacts with CD155/PVR and Nectin-2/CD112.Ligation of DNAM-1 promotes the activation of NK cells，CD8+ T cells，and mast cells，induces dendritic cell maturation，initiates megakaryocyte and activated platelet adhesion to vascular endothelial cells，and stimulates monocyte extravasation.Conversely，it inhibits the formation of osteoclasts.Platelet-endothelium interactions that are mediated by DNAM-1 enable the metastasis of tumor cells to the lung.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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