Recombinant Mouse Signaling Lymphocytic Activation Molecule/SLAM/CD150,BR

产品属性 Product Attributes

基本信息

别名： signaling lymphocytic activation molecule;SLAM family member 1;CD150 antigen;CD150;SLAMF1;SLAM
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Signaling lymphocyte activation molecule (SLAM)，is a self-ligand glycoprotein which exists not only found on the surface of activated and memory T cells，but also on the surface of activated B cells，dendritic cells，and macrophages.SLAM consists of a extracellular domain (ECD) with two Ig-like domains，transmembrane segment，and cytoplasmic domain with three immunoreceptor tyrosine switch motifs (ITSM).SLAM is thought to play an important role in adhesion between T cells and APCs and has been shown to act as a coreceptor in TCR-dependent responses.SLAM，together with CD46，is one of the two receptors for measles virus.SLAM is a cell surface receptor that，like the B cell receptor，CD40，and CD95，can transmit positive or negative signals.SLAM can associate with the SH2-containing inositol phosphatase (SHIP)，the SH2-containing protein tyrosine phosphatase (SHP-2)，and the adaptor protein SH2 domain protein 1A.It’s upregulated on activated B cells and CD4+ and CD8+ T cells，but downregulated on Th2 polarized cells.Also，it can Inhibits antigen receptor-mediated production of IFN-gamma，but not IL-2，in CD4-/CD8- T-cells
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。