Recombinant Mouse SLAMF4/Natural killer cell receptor 2B4/CD244,BR

产品属性 Product Attributes

基本信息

别名： Natural killer cell receptor 2B4;NK cell type I receptor protein 2B4;NKR2B4;SLAM family member 4;SLAMF4;Signaling lymphocytic activation molecule 4;CD244
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Natural killer cell receptor 2B4 (2B4/CD244)is a 66 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 protein family.SLAM family proteins have an extracellular domain (ECD) with two or four Ig-like domains and at least two cytoplasmic immunoreceptor tyrosine-based switch motifs (ITSMs).2B4 interacts with CD48，while other SLAM family proteins interact in a homophilic manner.The mouse 2B4 cDNA encodes a 397 amino acid (aa) precursor that includes a 19 aa signal sequence，a 207 aa ECD with one Ig-like V-type and one C2-type Ig-like domain，a 21 aa transmembrane segment，and a 150 aa cytoplasmic domain with four ITSMs.Within the ECD，mouse 2B4 shares 46% and 68% aa sequence identity with human and rat 2B4，respectively.2B4/CD48 signaling cooperates with other receptor systems to either promote or inhibit NK and CD8+ T cell activation.The inhibitory activities are distinct from those of MHC I restricted inhibitory NK cell receptors.Ligation of 2B4 with antibodies or CD48 constructs can directly trigger inhibitory signaling or disrupt an inhibitory interaction，leading to cellular activation.2B4 can also induce signaling through CD48.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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