Recombinant Human Langerin/CD207/C-type lectin domain family 4 member K/C-type lectin domain family 4, member K,BR

产品属性 Product Attributes

基本信息

别名： CD207 antigen;langerin;CD207;C-type lectin domain family 4 member K;C-type lectin domainfamily 4,member K
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Langerin (CD207) is a type II transmembrane glycoprotein which is member K of the C-type lectin domain family.Langerin is used as a marker for Langerhans cells (LCs) which represent the immature dendritic cells in the epidermis.Langerin is necessary and sufficient for Birbeck granule formation.Human langerin sequence contains a 43 aa cytoplasmic domain，a 21 aa transmembrane domain and a 264 aa extracellular domain (ECD) that contains a coiled-coil domain and a single C-type lectin domain.Human langerin shares 68%，62%，71% aa identity with mouse，rat and bovine langerin ECD，respectively.Trimerization greatly increases the lectin binding affinity.Langerin internalizes endogenous proteins such as type I procollagen.Internalization by LC is thought to lead to suppression of self reactions.Langerin also mediates endocytosis of non-peptide antigens containing mannose，N-acetyl glucosamine and fucose that are expressed by mycobacteria and fungae.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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