Recombinant Human GFER/HPO/FAD-linked sulfhydryl oxidase ALR,BR

产品属性 Product Attributes

基本信息

别名： FAD-linked sulfhydryl oxidase ALR;GFER;Augmenter of liver regeneration;hERV1;Hepatopoietin;GFER;ALR;HERV1;HPO
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins.GFER is widely expressed in various human tissues.They are two isoforms of this protein.Isoform 1 could regenerate the redox-active disulfide bonds in CHCHD4/MIA40，a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space.The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1，resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40，while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen.Isoform 2 may act as an autocrine hepatotrophic growth factor promoting liver regeneration.GFER could also induce the expression of S-adenosylmethionine decarboxyl-ase and ornithine decarboxylases (ODC).S-adenosylmethionine decarboxyl-ase and ornithine decarboxylases play an important role in the synthesis of polyamines.
来源： E.coli

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in 4mM HCl.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/μg(1 EU/μg)as determined by LAL test.

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