Recombinant Human TMED1,BR

产品属性 Product Attributes

基本信息

别名： IL1RL1-Binding Protein;Il1rl1l;IL1RL1LG;IL-1RL1LG;IL1RL1LGIL1RL1-binding protein;ST2L;T1/ST2 receptor binding protein;TMED1;Tp24
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： TMED1 (Transmembrane Emp24 domain-containing protein 1) is a member of the TMED family of proteins (gene name TMED1).The TMED family of proteins are localized to membranes of the early secretory pathway，including the endoplasmic reticulum and Golgi，and function in vesicular protein trafficking.TMED1 is a 59 kDa monomer and has been reported to exist as homodimer.It contains 1 GOLD domain and is widely expressed.TMED1 is important in regulating innate immune signaling through its interaction with ST2L.Specifically，the GOLD domain in TMED1 interacts with the TIR domain of ST2L，a receptor for IL 33.This interaction promotes ST2L association with IL-33，allowing downstream signaling cascade activating MAP kinases，p38，and JNK.Studies have shown knockdown of TMED-1 in HUVECs impairs the IL-33 induced response resulting in reduction of IL-6 and IL-8 productions.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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