Recombinant Human ARC/NOL3,BR

产品属性 Product Attributes

基本信息

别名： Nucleolar Protein 3;Apoptosis Repressor With CARD;Muscle-Enriched Cytoplasmic Protein;Myp;Nucleolar Protein of 30 kDa;Nop30
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 25mM TrisHCl, 1mM DTT, 1mM EDTA, 2mM β-ME, 20% Glycerol, pH 7.5.
纯度: ≥80% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： Nucleolar protein 3 is encoded by NOL3 gene.Multiple transcript variants encoding different isoforms have been found for this gene.So far，Nucleolar protein 3 has show to have two Isoforms.Isoform 1 may be involved in RNA splicing.Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death.It inhibits extrinsic apoptotic pathways through two different ways.Firstly，it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly.Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner，limiting the amount of soluble CASP8 available for DISC-mediated activation.It has been shown to down-regulate the enzyme activities of caspase 2，caspase 8 and tumor protein p53.
来源： E.coli

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

暂无数据

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。