Recombinant Human Ezrin/EZR/VIL2,BR

产品属性 Product Attributes

基本信息

别名： Ezrin;Cytovillin;Villin-2;p81;EZR;VIL2
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Suppliedas a 0.2 μm filtered solution of 10mM Hepes, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： Ezrin is expressed in cerebral cortex，basal ganglia，hippocampus，hypophysis，and optic nerve.The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains.The C-terminus contain a ERM domain.As a member of the ERM protein family，Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton.It plays a key role in cell surface structure adhesion，migration，and organization.Ezrin probably involved in connections of major cytoskeletal structures to the plasma membrane.The N-terminal FERM domain strongly binds sodium-hydrogen exchanger regulatory factor (NHERF) proteins (involving long-range allostery).The C-terminal binds to actin，phosphatidylinositol bis-phosphate (PIP2) and membrane proteins like CD44 and ICAM-2.In epithelial cells，Ezrin is required for the formation of microvilli and membrane ruffles on the apical pole.Along with PLEKHG6，Ezrin is required for normal macropinocytosis.
来源： E.coli

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。