Recombinant Human F13a/Coagulation Factor XIII A Chain,BR

产品属性 Product Attributes

基本信息

别名： Coagulation Factor XIII A Chain;Coagulation Factor XIIIa;Protein-Glutamine Gamma-Glutamyltransferase A Chain;Transglutaminase A Chain;F13A1;F13A
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 50 mM NaCl,5% Sucrose, 1% Tween 20 (v/v),0.3% Histidine (w/v),pH8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤ -70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade.Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits.The A subunits have catalytic function，and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules.Platelet factor XIII is composed of just 2 A subunits，which are identical to those of plasma origin.Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion，the plasma factor XIII dissociates its B subunits and yields the same active enzyme，factor XIIIa，as platelet factor XIII.This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules，thus stabilizing the fibrin clot.Factor XIII deficiency is classified into two categories: type I deficiency，characterized by the lack of both the A and B subunits; and type II deficiency，characterized by the lack of the A subunit alone.These defects can result in a lifelong bleeding tendency，defective wound healing，and habitual abortion.
来源： Human Cells

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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