Recombinant Human Endothelial protein C receptor/EPCR,BR

产品属性 Product Attributes

基本信息

别名： Endothelial Protein C Receptor;Activated Protein C Receptor;APC Receptor;Endothelial Cell Protein C Receptor;CD201;PROCR;EPCR
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Endothelial Protein C Receptor (EPCR) is a Vitamin K-dependent Serine Protease that plays a major role in blood coagulation.Binding of Protein C to EPCR leads to the proteolytic activation of PAR1 (Protease-Activated Receptor 1) on endothelial cells and subsequent up-regulation of Protein C-induced genes.EPCR is a type I transmembrane glycoprotein in the CD1/MHC family.It is expressed most strongly in the endothelial cells of arteries and veins in heart and lung.Membrane bound EPCR is released by metalloproteolytic cleavage to generate the soluble receptor.The extracellular domain of human and mouse EPCR shares approximately 61% amino acid sequence homology.EPCR plays an important role in augmenting Protein C activation by the Thrombin-Thrombomodulin complex and in regulating blood coagulation and inflammation.EPCR is found primarily on endothelial cells.Deletion of EPCR function results in embryonic death，at least in part due to placental thrombosis.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

产品介绍 Product Introduction

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