Recombinant Human CD19,BR

产品属性 Product Attributes

基本信息

别名： B-Lymphocyte Antigen CD19;B-Lymphocyte Surface Antigen B4;Differentiation Antigen CD19;T-Cell Surface Antigen Leu-12;CD19
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains.CD19 is expressed on follicular dendritic cells and B cells.In fact，it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells.CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81.Upon activation，the cytoplasmic tail of CD19 becomes phosphorylated，which leads to binding by Src-family kinases and recruitment of PI-3 kinase.CD19 Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) which is a primary immunodeficiency characterized by antibody deficiency，hypogammaglobulinemia，recurrent bacterial infections and an inability to mount an antibody response to antigen.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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