Recombinant Mouse IL-36 alpha/IL-36α/IL-1F6/IL-1 epsilon/Interleukin-36 alpha,BR

产品属性 Product Attributes

基本信息

别名： IL-36 alpha;IL-36α;Interleukin-36 alpha;Il36a;FIL1 epsilon;Interleukin-1 epsilon;IL-1 epsilon;nterleukin-1 family member 6;IL-1F6;Interleukin-1 homolog 1;IL-1H1;Fil1e;Il1e;Il1f6;Il1h1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Interleukin-36 alpha(Il-36a) is a member of the IL-1 family.IL-1α，IL-1β and IL-18 are potent inflammatory cytokines whose activities are dependent on heterodimeric receptors of the IL-1R superfamily，and which are regulated by soluble antagonists.Il36a is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response.It is a part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP.It seems to be involved in skin inflammatory response by acting on keratinocytes，dendritic cells and indirectly on T cells to drive tissue infiltration，cell maturation and cell proliferation.It Induces the production of proinflammatory cytokines，including IL-12，Il-1 beta，IL-6，TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs).Moreover，it is involved in dendritic cell maturation by stimulating the surface expression of CD80，CD86 and MHC class II and can induce the production of IFN-gamma，IL-4 and IL-17 by cultured CD4+ T cells and splenocytes.Il36a may play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung，and the expression of TNF-alpha，IL-36c，IL-1A，IL-1B，CXCL1 and CXCL2 in isolated splenic CD11c+ alveolar macrophages.It may be involved in T cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c+ cells and CD4+ T cell proliferation.
来源： E.coli

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。