Recombinant Human Dkk-2/Dickkopf-related protein 2,BR

Known as:Dickkopf-related protein 2; Dickkopf-2; Dkk-2; hDkk-2
Derived from:Human Cells
Purity:Greater than 95% as determined by reducing SDS-PAGE.
Formulation:Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.
Storage:Lyophilized protein should be stored at < -20°c,="" though="" stable="" at="" room="" temperature="" for="" 3="" weeks.reconstituted="" protein="" solution="" can="" be="" stored="" at="" 4-7°c="" for="" 2-7="" days.aliquots="" of="" reconstituted="" samples="" are="" stable="" at="">< -20°c="" for="" 3="">
Reconstitution:Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Endotoxin:Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Background:Dickkopf-related protein 2 (DKK2), is a member of the dickkopf family. DKK2 is secreted protein which contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
规格:10ug, 50ug, 500ug, 1mg, 注意：
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