Recombinant Human Cerberus 1/CER1,BR

产品属性 Product Attributes

基本信息

别名： Cerberus;Cerberus-Related Protein;DAN Domain Family Member 4;CER1;DAND4
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM NaAc-HACpH 4.5 .
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers.It is a cytokine member of the DAN domain family of BMP antagonists that includes DAN (DAND1)，Gremlin/Drm (DAND2)，PRDC (Protein Related to Dan and Cerberus，DAND3)，and COCO/Dante (DAND5).DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands.At the onset of gastrulation，Cerberus 1 is transiently expressed in anterior endodermal structures in response to Nodal and Shh.Cerberus 1 binds BMP-4 and Nodal and inhibits their activities.The inhibitory functions of Cerberus favor mesodermal development in the anterior region of the gastrula and suppresses posterior mesodermal differentiation.In chick and Xenopus，Cerberus 1 also regulates，but is not required for embryonic left-right polarization，neurulation，and head and heart induction.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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