Recombinant Mouse C5a/Complement Component C5,BR

产品属性 Product Attributes

基本信息

别名： Complement C5;Hemolytic Complement;C5;Hc
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 350mM NaCl, pH 7.5.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Mouse Complement C5 (C5a) is a glycoprotein that belongs to a family of structurally and functionally related proteins known as anaphylatoxins.C5a is a 77 amino acid peptide that is created by the C5a convertase proteolytic cleavage of C5 αchain in the classical and alternative complement pathway (C4b2a3b，C3bBb3b).Mouse C5a has fourαhelices，plus three intra-chain disulfide bonds that form a triple loop structure.C5a functions via G-protein coupled receptor (GPCR) (C5aR/CD88).C5a is a potent chemoattractant and anaphylatoxin that acts on all classes of leukocytes and on many other cell types including endothelial，smooth muscle，kidney，liver，and neural cells.It mediates IL-8 release from bronchial epithelial cells.It also triggers an oxidative burst in macrophages and neutrophils，causing release of histamine in basophils and mast cells.C5a anaphylatoxin activity on hepatocytes results indirectly from interaction with nonparenchymal cell via prostanoid secretion.Mouse C5a shares 60% and 82% sequence identity to human and rat C5a，respectively.
来源： E.coli

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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