Recombinant Human Importin Subunit Beta-1/KPNB1,BR

产品属性 Product Attributes

基本信息

别名： Importin subunit beta-1;Importin-90;Karyopherin subunit beta-1;Nuclear factor p97;Pore targeting complex 97 kDa subunit;PTAC97;KPNB1;NTF97
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 20mM Tris,1mM DTT,30% glycerol,0.1M Nacl,pH8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： Importin subunit beta-1(KPNB1) is a member of the importin beta family.KPNB1 contains 1 importin N-terminal domain and 19 HEAT repeats.It is involved in nucleocytoplasmic transport，a signal- and energy-dependent process，takes place through nuclear pore complexes embedded in the nuclear envelope.Its functions in nuclear protein import，either in association with an adapter protein，like an importin-alpha subunit，which binds to nuclear localization signals (NLS) in cargo substrates，or by acting as autonomous nuclear transport receptor.The import of proteins containing a classical nuclear localization signal (NLS) requires the NLS import receptor，a heterodimer of importin alpha and beta subunits.Each of these subunits is part of the karyopherin family of proteins.Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex.It mediates autonomously the nuclear import of ribosomal proteins RPL23A，RPS7 and RPL5.
来源： E.coli

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

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