Recombinant Mouse TIMP-2/Tissue Inhibitor of Metalloproteinases 2,BR

产品属性 Product Attributes

基本信息

别名： TIMP-2;CSC-21Ktissue inhibitor of metalloproteinase 2;metalloproteinase inhibitor 2;TIMP metalloproteinase inhibitor 2;Tissue inhibitor of metalloproteinase 2.
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： Mouse Metalloproteinase inhibitor 2(TIMP-2)，belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs).There are four mammalian members of the family; TIMP-1，TIMP-2，TIMP-3，and TIMP-4.The TIMP-2 is detected in testis，retina，hippocampus and cerebral cortex.The function of TIMP 2 protein is to inhibit MMPs non covalently by the formation of binary complexes.Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.And the interaction with MMP-14 facilitates the activation of pro-MMP-2.It has been shown that the binding of TIMP 2 to a3b1 integrin results in the inhibition of endothelial cell proliferation and angiogenesis.
来源： Human Cells

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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