Recombinant Human Caspase-14/CASP14,BR

产品属性 Product Attributes

基本信息

别名： Caspase-14;CASP-14;CASP14
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥85% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Caspase 14 (CASP14) is an enzyme that belongs to the peptidase C14A family.The Caspase 14 protein is complexed of unprocessed caspase-14 and processed 19 kDa (p19) and 10 kDa (p10) subunits.Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.Caspases exist as inactive proenzymes，which undergo proteolytic processing at conserved aspartic residues to produce two subunits，large and small，that dimerize to form the active enzyme.CASP14 has been shown to be processed and activated by Caspase 8 and Caspase 10 in vitro，and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo.The expression and processing of this caspase may be involved in keratinocyte terminal differentiation，which is important for the formation of the skin barrier.It is believed to be a non-apoptotic caspase which is involved in epidermal differentiation，keratinocyte differentiation and cornification.CASP14 probably regulates maturation of the epidermis by proteolytically processing filaggrin.
来源： E.coli

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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